Continuing the previously initiated research under the guidance of Professor Željko Svedružić († April 20, 2023), the scientific team from the University of Rijeka and the Center for Informatics and Computing at the Ruđer Bošković Institute in Croatia, has successfully applied for and secured funding for the implementation of the EHPC-BEN-2023B11-013 project on the LUMI supercomputer. This exceptionally powerful system, the HPE Cray EX, with an installed power of 0.3091 Exaflops, is located at the EuroHPC center CSC in Finland and proudly holds the status of the third most powerful supercomputer globally.
Through this EuroHPC project, the research team has been allocated a valuable 876.00 core hours, providing them with the resources needed for further exploration of the DNA methylation field. The research’s goal remains focused on finding new inhibitors of DNA methylation, and the results are expected to enable the development of efficient simulations of DNA structures within the millisecond timeframe.
These advanced investigations not only contribute to understanding the fundamental mechanisms of DNA methylation but also open up possibilities for developing new therapeutic approaches. Scientists are particularly hopeful that their efforts will lead to the discovery of novel DNA methylation inhibitors, the application of which could have a significant impact on the treatment of serious diseases such as cancer, Alzheimer’s, Parkinson’s, and other complex pathologies.
This research has the potential not only to expand our knowledge of molecular processes in the organism but also to lay the foundation for the development of targeted therapies that could revolutionize medical practice, all with a help of High-Performance Computing (HPC).